Treatment of organic bipolar mood disorders in Parkinson's disease

J Neuropsychiatry Clin Neurosci. 1994 Spring;6(2):181-4. doi: 10.1176/jnp.6.2.181.

Abstract

Two patients with long-standing idiopathic Parkinson's disease (PD), without individual or family histories of affective disorders, developed bipolar mood disorders. Both were treated with lithium and clozapine, and one responded favorably. These may be the first reported cases in which mania was treated with clozapine in PD patients.

Publication types

  • Case Reports

MeSH terms

  • Bipolar Disorder / chemically induced*
  • Bipolar Disorder / drug therapy
  • Bipolar Disorder / psychology
  • Clozapine / adverse effects
  • Clozapine / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Levodopa / adverse effects*
  • Levodopa / therapeutic use
  • Lithium Carbonate / adverse effects
  • Lithium Carbonate / therapeutic use*
  • Male
  • Middle Aged
  • Parkinson Disease / diagnosis
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / psychology
  • Psychoses, Substance-Induced / diagnosis
  • Psychoses, Substance-Induced / drug therapy*
  • Psychoses, Substance-Induced / psychology
  • Recurrence

Substances

  • Lithium Carbonate
  • Levodopa
  • Clozapine