Abstract
Chelerythrine and sanguinarine, two structurally related benzo/c/phenanthridine alkaloids, prevented growth of yeast cells in medium containing either glucose or non-fermentable carbon sources. At concentrations permitting growth of the yeast Saccharomyces cerevisiae, chelerythrine, but not sanquinarine, induced cytoplasmic respiration-deficient mutants. The petite clones that were analysed exhibited suppressiveness and contained different fragments of the wild-type mitochondrial genome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / pharmacology*
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Anti-Bacterial Agents / pharmacology*
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Benzophenanthridines
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DNA, Mitochondrial / drug effects
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Isoquinolines
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Microbial Sensitivity Tests
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Mutation / genetics*
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Oxygen Consumption / drug effects
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Oxygen Consumption / genetics*
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Phenanthridines / pharmacology*
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Saccharomyces cerevisiae / drug effects
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / growth & development
Substances
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Alkaloids
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Anti-Bacterial Agents
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Benzophenanthridines
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DNA, Mitochondrial
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Isoquinolines
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Phenanthridines
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sanguinarine
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chelerythrine