Brucellosis is an infectious zoonosis. It is a occupational disease of stock-breeders, workers of slaughter houses and veterinarians. Brucellosis is characterized by a variety of clinical symptoms and involves several organs of the body. Skeletal manifestations often facilitate diagnosis. Difficulties in diagnosis of brucellosis in Poland are resulted from an increased amount of low-symptomatic or asymptomatic cases, a decrease in acute brucellosis and mild course of chronic disease. Therapy is related to the stage of the disease, antibiotics are required in acute brucellosis. Symptomatic treatment with special emphasis to neurological and psychiatric management is used in patients with chronic brucellosis. Early made diagnosis is important because undiagnosed disease leads to severe disability and loss of work ability.