Efficacy of a resorbable hydrogel barrier, oxidized regenerated cellulose, and hyaluronic acid in the prevention of ovarian adhesions in a rabbit model

Fertil Steril. 1994 Sep;62(3):630-4. doi: 10.1016/s0015-0282(16)56956-8.

Abstract

Objective: To compare the efficacy of a resorbable hydrogel material with oxidized regenerated cellulose and hyaluronic acid in an ovarian adhesion model.

Design: Controlled, blinded, and randomized study involving female rabbits.

Setting: Academic research environment.

Interventions: A water-soluble hydrogen precursor was applied to the ovary as a liquid and converted to a hydrogel by exposure to long wavelength ultraviolet light, a 0.4% solution of hyaluronic acid was applied to the ovary, or an oxidized regenerated cellulose patch was applied to the ovary after wedge resectioning.

Main outcome measures: Extent and severity of adhesion formation.

Results: Application of the hydrogel reduced adhesion formation by 88%. Neither oxidized regenerated cellulose nor hyaluronic acid reduced adhesion formation.

Conclusion: The photopolymerized, resorbable hydrogel material is highly effective for the reduction of periovarian adhesions in this model.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cellulose / chemistry
  • Cellulose / therapeutic use*
  • Female
  • Hyaluronic Acid / therapeutic use*
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Ovarian Diseases / pathology
  • Ovarian Diseases / prevention & control*
  • Ovary / pathology
  • Oxidation-Reduction
  • Polyethylene Glycols / therapeutic use*
  • Rabbits
  • Regeneration
  • Tissue Adhesions / pathology
  • Tissue Adhesions / prevention & control

Substances

  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Polyethylene Glycols
  • Cellulose
  • Hyaluronic Acid