Recently the role of rotavirus in the etiopathogenesis of neonatal hemorrhagic gastroenteritis and necrotizing enterocolitis has been underlined. We report a case of NEC caused by rotavirus, that occurred in a term neonate born from a drug abusing mother, during an outbreak of rotavirus-associated which appeared with gastrointestinal bleeding and mild systemic signs in comparison with marked radiologic findings, rapidly evolved from the fourth day of life, after the normalization of abdominal roentgenogram.