Dual-action inhibitors of proteolytic enzymes: potential therapeutic agents for cystic fibrosis and related ailments

Bioorg Med Chem. 1993 Oct;1(4):273-7. doi: 10.1016/s0968-0896(00)82132-x.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Aspirin / analogs & derivatives
  • Aspirin / chemical synthesis
  • Aspirin / pharmacology
  • Cystic Fibrosis / drug therapy*
  • Cystic Fibrosis / enzymology
  • Drug Design
  • Humans
  • In Vitro Techniques
  • Ketoprofen / analogs & derivatives
  • Ketoprofen / chemical synthesis
  • Ketoprofen / pharmacology
  • Kinetics
  • Leukocytes / enzymology
  • Molecular Sequence Data
  • Molecular Structure
  • Oligopeptides / chemistry
  • Pancreatic Elastase / antagonists & inhibitors*
  • Pancreatic Elastase / blood
  • Protease Inhibitors / chemical synthesis
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology*
  • Saccharin / analogs & derivatives
  • Saccharin / chemical synthesis
  • Saccharin / pharmacology
  • Structure-Activity Relationship

Substances

  • Oligopeptides
  • Protease Inhibitors
  • Ketoprofen
  • Pancreatic Elastase
  • Saccharin
  • Aspirin