Abstract
Primary cultures of human gastric epithelial cells were tested for induction of unscheduled DNA synthesis (UDS) by sterigmatocystin (ST) and T-2 toxin. Autoradiographic results indicated that ST (10(-6)-10(-4)M) induced UDS in the presence of S9 activation system. The repair rates were 24-91% (net grains > or = 3) and 2-71% (net grains > or = 5). T-2 toxin did not induce UDS in this study.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Autoradiography
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Biotransformation
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Cell Division / drug effects
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Cell Survival / drug effects
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Cells, Cultured
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DNA / biosynthesis*
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Dose-Response Relationship, Drug
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Epithelial Cells
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Epithelium / drug effects
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Gastric Mucosa / cytology
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Gastric Mucosa / drug effects*
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Gastric Mucosa / metabolism
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Humans
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Microsomes, Liver / drug effects
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Microsomes, Liver / metabolism
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Rats
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Sterigmatocystin / pharmacokinetics
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Sterigmatocystin / toxicity*
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T-2 Toxin / pharmacokinetics
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T-2 Toxin / toxicity*
Substances
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Sterigmatocystin
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DNA
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T-2 Toxin