Abstract
An elastase-like protease, recently recognized as a specific product of murine T cells, may functionally associate with the classical TCR. T cell elastase, found in combination with the natural elastase inhibitor alpha 1-antitrypsin (alpha 1-protease inhibitor, alpha 1-PI), is produced by both CD4+ and CD8+ T lymphocytes. T cell elastase and alpha 1-PI are found chemically associated with the TCR in an antigen-specific complex reminiscent of the Ig-complement 'immune complexes'.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigen-Antibody Complex / immunology*
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Antigen-Antibody Complex / isolation & purification
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Blotting, Western
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CD4 Antigens / immunology
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CD4-Positive T-Lymphocytes / enzymology
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CD4-Positive T-Lymphocytes / immunology
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CD8 Antigens / immunology
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Chromatography, Affinity
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Electrophoresis, Polyacrylamide Gel
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Enzyme-Linked Immunosorbent Assay
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Hemolytic Plaque Technique
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Hypersensitivity, Delayed
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Immunity, Cellular
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Mice
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Mice, Inbred C57BL
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Pancreatic Elastase / metabolism*
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Receptors, Antigen, T-Cell / immunology*
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T-Lymphocytes / enzymology
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T-Lymphocytes / immunology*
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alpha 1-Antitrypsin / immunology
Substances
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Antigen-Antibody Complex
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CD4 Antigens
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CD8 Antigens
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Receptors, Antigen, T-Cell
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alpha 1-Antitrypsin
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Pancreatic Elastase