The sigma receptor ligand SR 31742A increases neurotensin in the nucleus accumbens but not in the caudate-putamen of the rat

Eur J Pharmacol. 1993 Feb 16;231(3):465-7. doi: 10.1016/0014-2999(93)90125-2.

Abstract

The effects of SR 31742A, a specific sigma site ligand, were investigated on regional neurotensin concentrations in rat brain. Both acute and chronic (21-day) treatment with either SR 31742A (20 mg/kg i.p.) or haloperidol (1 mg/kg i.p.) increased the neurotensin-like immunoreactivity in the nucleus accumbens. In contrast to haloperidol, the administration of SR 31742A failed to increase the concentration of neurotensin-like immunoreactivity in the caudate-putamen. Thus, the effects of SR 31742A appear to be selective for the limbic system.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antipsychotic Agents / pharmacology*
  • Azepines / pharmacology*
  • Caudate Nucleus / drug effects*
  • Caudate Nucleus / metabolism
  • Dose-Response Relationship, Drug
  • Haloperidol / pharmacology
  • Injections, Intraperitoneal
  • Neurotensin / metabolism*
  • Nucleus Accumbens / drug effects*
  • Nucleus Accumbens / metabolism
  • Putamen / drug effects*
  • Putamen / metabolism
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Antipsychotic Agents
  • Azepines
  • 3-(hexahydroazepin-1-yl)-1-(3-chloro-4-cyclohexylphenyl)-1-propene hydrochloride
  • Neurotensin
  • Haloperidol