Abstract
Nineteen French breast and breast-ovarian cancer families were tested for linkage with five chromosome 17q markers. The five breast-ovarian cancer families as a group give positive evidence for linkage, whereas the 14 breast cancer-only families do not. Heterogeneity of linkage of breast and breast-ovarian cancers is significant in France and supports the existence of more than one susceptibility gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Breast Neoplasms / genetics*
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Chi-Square Distribution
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Chromosome Mapping / methods*
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Chromosomes, Human, Pair 17*
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Family Health
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Female
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France
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Genetic Linkage
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Genetic Markers
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Genetic Predisposition to Disease
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Genetic Variation
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Humans
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Lod Score
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Male
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Middle Aged
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Neoplastic Syndromes, Hereditary / genetics
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Ovarian Neoplasms / genetics
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Pedigree
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Polymorphism, Restriction Fragment Length
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Proto-Oncogenes*