The synthesis of trans-3,4-bis-(3,4-dihydroxyphenyl)pyrrolidine, a novel DA1 agonist

Chem Pharm Bull (Tokyo). 1993 Mar;41(3):633-5. doi: 10.1248/cpb.41.633.

Abstract

The synthesis of trans-3,4-bis-(3,4-dihydroxyphenyl)pyrrolidine by the Michael reaction of esterenolate with nitro olefin is described. This compound was expected to be the agonist toward dopamine (DA1) receptor with equipotent affinity and to be more selective than dopamine itself.

MeSH terms

  • Animals
  • Catechols / chemical synthesis*
  • Catechols / pharmacology
  • Dogs
  • Dopamine Agents / chemical synthesis*
  • Dopamine Agents / pharmacology
  • Hemodynamics / drug effects*
  • Pyrrolidines / chemical synthesis*
  • Pyrrolidines / pharmacology
  • Radioligand Assay
  • Rats
  • Receptors, Dopamine D1 / drug effects*
  • Renal Circulation / drug effects

Substances

  • Catechols
  • Dopamine Agents
  • Pyrrolidines
  • Receptors, Dopamine D1
  • 3,4-bis(3,4-dihydroxyphenyl)pyrrolidine