Abstract
Twenty-eight primary small cell carcinomas of the cervix uteri were examined immunohistochemically for overexpression of p53 protein and c-erbB-2 protein. Twenty-one per cent of the cases showed positive immunostaining for p53 protein, whereas no staining was observed using the antibody against c-erbB-2. Our results indicate that altered expression of p53 protein may be involved in the development of small cell carcinoma of the cervix uteri.
MeSH terms
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Biomarkers, Tumor / analysis*
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Carcinoma, Small Cell / pathology*
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Female
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Humans
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Immunoenzyme Techniques
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Immunohistochemistry
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Proto-Oncogene Proteins / analysis*
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Proto-Oncogene Proteins / biosynthesis
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Receptor, ErbB-2
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Tumor Suppressor Protein p53 / analysis*
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Tumor Suppressor Protein p53 / biosynthesis
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Uterine Cervical Neoplasms / pathology*
Substances
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Biomarkers, Tumor
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Proto-Oncogene Proteins
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Tumor Suppressor Protein p53
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Receptor, ErbB-2