Precise localization on chromosome 12 of the ATF-1 gene by fluorescence in situ hybridization

C Desmaze; J Zucman; O Delattre; T Melot; G Thomas; A Aurias

doi:10.1007/BF00210613

Precise localization on chromosome 12 of the ATF-1 gene by fluorescence in situ hybridization

Hum Genet. 1994 Feb;93(2):207-8. doi: 10.1007/BF00210613.

Authors

C Desmaze¹, J Zucman, O Delattre, T Melot, G Thomas, A Aurias

Affiliation

¹ Laboratoire de Génétique des Tumeurs, INSERM CJF 9201, Institut Curie, Paris, France.

PMID: 8112749
DOI: 10.1007/BF00210613

Abstract

The ATF-1 gene encodes for a transcription factor normally regulated by cAMP (Hai et al. 1989, Yoshimura et al. 1990). Recently, it has been shown to be involved in the recurrent t(12;22) translocation observed in soft tissue malignant melanoma, in a fusion gene with the EWS gene (Zucman et al. 1993). We report here on its precise localization on chromosome 12 by fluorescence in situ hybridization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Activating Transcription Factor 1
Chromosomes, Human, Pair 12 / chemistry*
DNA-Binding Proteins*
Humans
In Situ Hybridization, Fluorescence / methods*
Transcription Factors / genetics*

Substances

Activating Transcription Factor 1
DNA-Binding Proteins
Transcription Factors