Malignant histiocytosis with multiple skin lesions in a dog

J Vet Med Sci. 1993 Dec;55(6):1059-61. doi: 10.1292/jvms.55.1059.

Abstract

A 7-year-old male Yorkshire terrier was examined for multiple plaques and nodules on the skin. The clinical, cytological and histopathological features indicated a malignant histiocytosis. Cytoreductive chemotherapy produced moderate clinical improvement, but died at day 90 after the first admission. Pathological examination revealed the neoplastic histiocytes in the skin as well as in the myocardium and skeletal muscles.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Antigens, Neoplasm / analysis
  • Antigens, Surface / analysis
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cyclophosphamide / administration & dosage
  • Dacarbazine / administration & dosage
  • Dog Diseases*
  • Dogs
  • Heart Neoplasms / diagnosis
  • Heart Neoplasms / drug therapy
  • Heart Neoplasms / pathology
  • Heart Neoplasms / veterinary
  • Histiocytic Sarcoma / diagnosis
  • Histiocytic Sarcoma / drug therapy
  • Histiocytic Sarcoma / pathology
  • Histiocytic Sarcoma / veterinary*
  • Male
  • Mitoxantrone / administration & dosage
  • Muscles / pathology
  • Myocardium / pathology
  • Prednisolone / administration & dosage
  • Skin / pathology
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / pathology
  • Skin Neoplasms / veterinary*
  • Vincristine / administration & dosage

Substances

  • Antigens, Neoplasm
  • Antigens, Surface
  • Vincristine
  • Dacarbazine
  • Cyclophosphamide
  • Prednisolone
  • Mitoxantrone