Relevance of chlorine-substituent for the antifungal activity of syringomycin and syringotoxin, metabolites of the phytopathogenic bacterium Pseudomonas syringae pv. syringae

I Grgurina; A Barca; S Cervigni; M Gallo; A Scaloni; P Pucci

doi:10.1007/BF01984950

Relevance of chlorine-substituent for the antifungal activity of syringomycin and syringotoxin, metabolites of the phytopathogenic bacterium Pseudomonas syringae pv. syringae

Experientia. 1994 Feb 15;50(2):130-3. doi: 10.1007/BF01984950.

Authors

I Grgurina¹, A Barca, S Cervigni, M Gallo, A Scaloni, P Pucci

Affiliation

¹ Dipartimento di Scienze Biochimiche A. Rossi-Fanelli, Università La Sapienza di Roma, Italy.

PMID: 8125171
DOI: 10.1007/BF01984950

Abstract

Structural analogues of syringomycin and syringotoxin were produced by fermentation, characterized by FAB-MS and amino acid analysis and compared to the parent compounds in the antibiosis test against Rhodotorula pilimanae. The C-terminal residue was shown to be important for the activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Antifungal Agents / pharmacology*
Bacterial Proteins / chemistry
Bacterial Proteins / pharmacology*
Bacterial Toxins / chemistry
Bacterial Toxins / pharmacology*
Molecular Sequence Data
Peptides, Cyclic*
Pseudomonas / drug effects*
Pseudomonas / pathogenicity
Structure-Activity Relationship

Substances

Antifungal Agents
Bacterial Proteins
Bacterial Toxins
Peptides, Cyclic
syringomycin
syringotoxin B