Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity

J Med Chem. 1994 Mar 4;37(5):560-2. doi: 10.1021/jm00031a002.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Absorption
  • Animals
  • Anticholesteremic Agents / chemical synthesis*
  • Anticholesteremic Agents / pharmacokinetics
  • Anticholesteremic Agents / therapeutic use
  • Biological Availability
  • Carbamates / chemical synthesis*
  • Carbamates / pharmacokinetics
  • Carbamates / therapeutic use
  • Cholesterol / metabolism
  • Cholesterol Esters / metabolism
  • Hydrogen-Ion Concentration
  • Hypercholesterolemia / prevention & control
  • Imidazoles / pharmacology
  • Lipids / blood*
  • Liver / metabolism
  • Microsomes, Liver / enzymology
  • Phenylurea Compounds / pharmacology
  • Rats
  • Solubility
  • Sterol O-Acyltransferase / antagonists & inhibitors*
  • Urea / analogs & derivatives
  • Urea / pharmacology
  • Water

Substances

  • Anticholesteremic Agents
  • Carbamates
  • Cholesterol Esters
  • Imidazoles
  • Lipids
  • Phenylurea Compounds
  • Water
  • ((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester
  • Urea
  • CL 277082
  • Cholesterol
  • lecimibide
  • Sterol O-Acyltransferase