Abstract
The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal
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B-Lymphocytes / immunology*
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Cell Line
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Cells, Cultured
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Female
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Genetic Linkage
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Interleukin-7 / metabolism*
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Interleukin-7 / pharmacology
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Mice
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Mice, Inbred C57BL
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Receptors, Interleukin / metabolism*
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Receptors, Interleukin-2 / genetics
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Receptors, Interleukin-2 / immunology
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Receptors, Interleukin-2 / metabolism*
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Receptors, Interleukin-7
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Severe Combined Immunodeficiency / genetics
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Severe Combined Immunodeficiency / immunology
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T-Lymphocytes / immunology*
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X Chromosome
Substances
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Antibodies, Monoclonal
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Interleukin-7
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Receptors, Interleukin
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Receptors, Interleukin-2
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Receptors, Interleukin-7