Abstract
New bengazoles 3-9 as inseparable mixtures are reported from the sponge Jaspis cf. coricea collected in Papua New Guinea. These compounds contain a new variation of the unusual bisoxazole core present in bengazole A [1]. The B-ring oxazole hexatetraol side chain is varyingly substituted with either myristic acid or 13-methylmyristic acid. Hydrolysis of three different bengazole mixtures each yielded an identical tetraol, bengazole Z [11].
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Colonic Neoplasms / drug therapy
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Drug Screening Assays, Antitumor
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Humans
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Hydrolysis
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Melanoma / drug therapy
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Oxazoles / chemistry*
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Oxazoles / isolation & purification
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Oxazoles / pharmacology
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Porifera / chemistry*
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Tumor Cells, Cultured
Substances
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Alkaloids
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Antineoplastic Agents
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Oxazoles
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bengazole A