Abstract
Transforming growth factor-beta (TGF-beta) and activin exert their effects by binding to heteromeric complexes of type I and type II receptors. The type II receptors for TGF-beta and activin are transmembrane serine-threonine kinases; a series of related receptors, denoted activin receptor-like kinase (ALK) 1 to 5, have recently been identified, and ALK-6 is described here. ALK-5 has been shown to be a functional TGF-beta type I receptor. A systematic analysis revealed that most ALKs formed heteromeric complexes with the type II receptors for TGF-beta and activin after overexpression in COS cells; however, among the six ALKs, only ALK-5 was a functional TGF-beta type I receptor for activation of plasminogen activator inhibitor-1, and only ALK-2 and ALK-4 bound activin with high affinity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Activin Receptors
-
Activins
-
Amino Acid Sequence
-
Animals
-
Bone Morphogenetic Protein Receptors, Type I
-
Cell Line
-
Inhibins / metabolism*
-
Ligands
-
Mice
-
Molecular Sequence Data
-
Protein Serine-Threonine Kinases / chemistry
-
Protein Serine-Threonine Kinases / metabolism*
-
Receptors, Growth Factor / chemistry
-
Receptors, Growth Factor / metabolism*
-
Receptors, Transforming Growth Factor beta / chemistry
-
Receptors, Transforming Growth Factor beta / metabolism*
-
Transforming Growth Factor beta / metabolism*
Substances
-
Ligands
-
Receptors, Growth Factor
-
Receptors, Transforming Growth Factor beta
-
Transforming Growth Factor beta
-
Activins
-
Inhibins
-
Protein Serine-Threonine Kinases
-
Activin Receptors
-
BMPR1B protein, human
-
Bmpr1b protein, mouse
-
Bone Morphogenetic Protein Receptors, Type I