Role of the beta-amyloid precursor protein in Alzheimer's disease

Trends Biochem Sci. 1994 Jan;19(1):42-6. doi: 10.1016/0968-0004(94)90173-2.

Abstract

Deposition of beta-amyloid peptide in the brain is an early event in Alzheimer's disease, the most common cause of dementia. Studies of the beta-amyloid precursor protein (APP), which gives rise to beta-amyloid, are rapidly leading to a better understanding of the biochemical basis of the disease--a prerequisite for rational drug development.

Publication types

  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / etiology
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Amino Acid Sequence
  • Amyloid beta-Protein Precursor / chemistry
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / physiology*
  • Brain / metabolism
  • Humans
  • Middle Aged
  • Molecular Sequence Data
  • Point Mutation
  • Protein Processing, Post-Translational

Substances

  • Amyloid beta-Protein Precursor