Discobahamins A and B, new peptides from the Bahamian deep water marine sponge Discodermia sp

S P Gunasekera; S A Pomponi; P J McCarthy

doi:10.1021/np50103a011

Discobahamins A and B, new peptides from the Bahamian deep water marine sponge Discodermia sp

J Nat Prod. 1994 Jan;57(1):79-83. doi: 10.1021/np50103a011.

Authors

S P Gunasekera¹, S A Pomponi, P J McCarthy

Affiliation

¹ Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34936.

PMID: 8158168
DOI: 10.1021/np50103a011

Abstract

Discobahamin A [1] and discobahamin B [2] are two bioactive peptides isolated from a new species of the Bahamian deep water marine sponge Discodermia. The discobahamins are inhibitors of the growth of Candida albicans, and the isolation and structure elucidation of 1 and 2 by nmr and chemical methods is described.

MeSH terms

Amino Acid Sequence
Animals
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Bahamas
Candida albicans / drug effects
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Porifera / chemistry*
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet

Substances

Antifungal Agents
Peptides, Cyclic
discobahamin A
discobahamin B