[Therapeutic effect of lisuride maleate on post-stroke depression]

Nihon Ronen Igakkai Zasshi. 1994 Jan;31(1):52-9. doi: 10.3143/geriatrics.31.52.
[Article in Japanese]

Abstract

Twenty post-stroke depressive patients who obtained more than 11 points on Self-Rating Questionnaire for Depression, were treated with 0.075 mg/day lisuride maleate for 12 weeks. The drug effect on depression was evaluated quantitatively by the Hamilton Rating Scale for Depression. The relationships between brain CT or MRI and SRQ-D score were investigated in 24 subjects. More than 80% of post-stroke depressive patients improved after lisuride maleate treatment for 8 or 12 weeks. In particular, depressed mood, hypobulia, sleep disturbance, anxiety, etc. were significantly improved compared to the baseline condition. As for the relationships with CT and/or MRI findings, the group with moderate to severe brain atrophy had a significantly higher grade of depressive state than those without.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Aged
  • Cerebrovascular Disorders / complications*
  • Depression / drug therapy*
  • Depression / etiology
  • Female
  • Humans
  • Lisuride / therapeutic use*
  • Male
  • Middle Aged

Substances

  • Lisuride