Acute myocardial infarction after artificially induced abortion is an uncommon event because such patients are usually young females and are not usually subject to atherosclerosis. This report describes two premenopausal females who developed acute myocardial infarction after administration of ergot derivatives which were used following abortion. Coronary arteries in both cases were angiographically normal. Both patients were smokers. We concluded that the ischemic event was caused by coronary vasospasm which was precipitated by the acute administration of ergot derivatives.