The tissue-specific RNA-binding protein COLBP is differentially regulated during myogenesis

T Preiss; Z M Chrzanowska-Lightowlers; R N Lightowlers

doi:10.1016/0167-4889(94)90252-6

The tissue-specific RNA-binding protein COLBP is differentially regulated during myogenesis

Biochim Biophys Acta. 1994 Apr 28;1221(3):286-9. doi: 10.1016/0167-4889(94)90252-6.

Authors

T Preiss¹, Z M Chrzanowska-Lightowlers, R N Lightowlers

Affiliation

¹ Division of Clinical Neuroscience, University of Newcastle upon Tyne, Medical School, UK.

PMID: 8167150
DOI: 10.1016/0167-4889(94)90252-6

Abstract

Cytochrome c oxidase L-form transcript-binding protein (COLBP) activity parallels the tissue-specific mRNA expression of bovine cytochrome c oxidase liver isopeptides. A similar RNA-binding activity is found in human myoblast and liver Hep G2 cell homogenates. Human COLBP activity, however, is not present in myotubes or adult skeletal muscle. It is proposed that COLBP down-regulation during muscle cell differentiation may underlie oxidase isoform switching during myogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Cell Differentiation
Down-Regulation
Electron Transport Complex IV / genetics*
Gene Expression Regulation, Enzymologic*
Glutamate Dehydrogenase / biosynthesis*
Humans
Liver / enzymology
Muscles / enzymology*
Myocardium / enzymology
RNA-Binding Proteins / biosynthesis*

Substances

RNA-Binding Proteins
Glutamate Dehydrogenase
Electron Transport Complex IV