Oral cytomegalovirus infection in an unrelated bone marrow transplantation with possible mediation by graft-versus-host disease and the use of cyclosporin-A

Oral Surg Oral Med Oral Pathol. 1994 Mar;77(3):248-53. doi: 10.1016/0030-4220(94)90293-3.

Abstract

Graft-versus-host disease remains as a significant sequela in allogeneic bone marrow transplantation patients. Reports of oral presentations of cytomegalovirus infection in this patient population are rare. Although the usual manifestation of oral cytomegalovirus is mucosal ulceration, we report a case that we believe reflects a dynamic among graft-versus-host disease, cytomegalovirus, and the use of cyclosporin A, commonly used as an immunosuppressive agent in bone marrow transplantation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Marrow Transplantation / adverse effects*
  • Cyclosporine / adverse effects*
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / etiology*
  • Female
  • Graft vs Host Disease / complications*
  • Graft vs Host Disease / drug therapy
  • Graft vs Host Disease / etiology
  • Humans
  • Immunocompromised Host
  • Immunoenzyme Techniques
  • Lymphoma, Follicular / therapy
  • Mouth Diseases / complications
  • Mouth Diseases / microbiology*
  • Mouth Mucosa / microbiology
  • Mouth Mucosa / pathology
  • Tongue Diseases / complications
  • Tongue Diseases / microbiology
  • Ulcer / microbiology

Substances

  • Cyclosporine