Successful administration of low molecular weight heparin in a patient with heparin-induced thrombocytopenia and coumarin-induced skin necrosis

Haemostasis. 1993 Sep-Oct;23(5):259-62. doi: 10.1159/000216884.

Abstract

A case of heparin-induced thrombocytopenia and skin necrosis induced by coumarin is reported in a 58-year-old female patient suffering from metastatic breast adenocarcinoma and deep vein thrombosis. The thrombosis resolved after treatment with low molecular weight heparin and the thrombocytopenia recovered within a few days. The occurrence of both these rare complications in the same patient has not been previously reported in the literature. We present a review of these complications and their current treatment.

Publication types

  • Case Reports

MeSH terms

  • Acenocoumarol / adverse effects*
  • Adenocarcinoma / complications
  • Adenocarcinoma / secondary
  • Adenocarcinoma / therapy
  • Breast Neoplasms / pathology
  • Combined Modality Therapy
  • Enoxaparin / therapeutic use*
  • Female
  • Gastrointestinal Hemorrhage / chemically induced
  • Heparin / adverse effects*
  • Humans
  • Middle Aged
  • Necrosis
  • Skin / pathology*
  • Spinal Neoplasms / complications
  • Spinal Neoplasms / secondary
  • Spinal Neoplasms / therapy
  • Thrombocytopenia / chemically induced*
  • Thrombophlebitis / complications
  • Thrombophlebitis / drug therapy*

Substances

  • Enoxaparin
  • Heparin
  • Acenocoumarol