Abstract
We have characterized a new human gene, named GARP, localized in the 11q14 chromosomal region. GARP comprises two coding exons, is expressed as two major transcripts of 4.4 and 2.8 kilobases, respectively, and encodes a putative transmembrane protein of 662 amino acids, the extracellular portion of which is almost entirely made of leucine-rich repeats. The molecular weight of the protein immunoprecipitated from transfected cells is 80,000. The GARP protein has structural similarities with the human GP Ib alpha and GP V platelet proteins, and with the Chaoptin, Toll, and Connectin adhesion molecules of Drosophila.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosome Mapping
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Chromosomes, Human, Pair 11*
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Connectin
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DNA, Complementary / analysis
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Drosophila / genetics
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Drosophila Proteins*
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Exons
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Gene Library
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Humans
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Insect Hormones / chemistry
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Leucine
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Membrane Glycoproteins / chemistry
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Membrane Proteins / chemistry
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Membrane Proteins / genetics*
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Mice
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Molecular Sequence Data
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Multigene Family*
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Muscle Proteins / chemistry
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Platelet Membrane Glycoproteins / chemistry
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Protein Kinases*
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Receptors, Cell Surface*
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Repetitive Sequences, Nucleic Acid
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Restriction Mapping
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Sequence Homology, Amino Acid
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Toll-Like Receptors
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Transcription, Genetic
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Transfection
Substances
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Connectin
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DNA, Complementary
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Drosophila Proteins
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Insect Hormones
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LRRC32 protein, human
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Lrrc32 protein, mouse
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Membrane Glycoproteins
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Membrane Proteins
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Muscle Proteins
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Platelet Membrane Glycoproteins
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Receptors, Cell Surface
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TTN protein, human
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Tl protein, Drosophila
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Toll-Like Receptors
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chp protein, Drosophila
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Protein Kinases
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Leucine