Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines

M E Wall; M C Wani; F Fullas; J B Oswald; D M Brown; T Santisuk; V Reutrakul; A T McPhail; N R Farnsworth; J M Pezzuto

doi:10.1021/jm00036a012

Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines

J Med Chem. 1994 May 13;37(10):1465-70. doi: 10.1021/jm00036a012.

Authors

M E Wall¹, M C Wani, F Fullas, J B Oswald, D M Brown, T Santisuk, V Reutrakul, A T McPhail, N R Farnsworth, J M Pezzuto, et al.

Affiliation

¹ Research Triangle Institute, Research Triangle Park, North Carolina 27709.

PMID: 8182705
DOI: 10.1021/jm00036a012

Abstract

Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Benzopyrans / pharmacology
Drug Screening Assays, Antitumor
Flavonoids / chemistry
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Humans
Mice
Models, Molecular
Molecular Conformation
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Benzopyrans
Flavonoids
calycopterone

Grants and funding

NCI UO1-CA-52956/CA/NCI NIH HHS/United States