Abstract
The synthesis of some 5-substituted 4-isoxazoleacetic acids starting from 5-substituted 4-isoxazolemethanols via their conversion to 4-(bromomethyl)isoxazoles, 4-isoxazoleacetonitriles and acid hydrolysis of the latter is described. 5-Ethyl- and 5-propyl-4-isoxazoleacetic acids showed in the writhing test an analgesic activity comparable to that of aspirin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemical synthesis*
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Acetates / pharmacology
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Acetates / toxicity
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Analgesics / chemical synthesis*
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Analgesics / pharmacology
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Analgesics / toxicity
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Animals
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Behavior, Animal / drug effects
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Carrageenan
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Edema / chemically induced
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Edema / prevention & control
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Isoxazoles / chemical synthesis*
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Isoxazoles / pharmacology
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Isoxazoles / toxicity
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Mice
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Pain Measurement / drug effects
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Rats
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Spectrophotometry, Infrared
Substances
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Acetates
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Analgesics
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Isoxazoles
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Carrageenan