Precise mapping of the EGF receptor gene on the human chromosome 7p12 using an improved fish technique

Y Wang; S Minoshima; N Shimizu

doi:10.1007/BF01907986

Precise mapping of the EGF receptor gene on the human chromosome 7p12 using an improved fish technique

Jpn J Hum Genet. 1993 Dec;38(4):399-406. doi: 10.1007/BF01907986.

Authors

Y Wang¹, S Minoshima, N Shimizu

Affiliation

¹ Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.

PMID: 8186417
DOI: 10.1007/BF01907986

Abstract

The gene for epidermal growth factor receptor (EGFR) has been localized to the p14-p12 region of human chromosome 7 by somatic cell hybridization and radioisotope in situ hybridization techniques. In this paper, we report the precise mapping of the EGFR gene to the band p12 of chromosome 7 using a novel method in which fluorescence images from in situ hybridization and Q-banding are computer graphically merged. The novel procedure is described in detail.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 7*
ErbB Receptors / genetics*
Humans
In Situ Hybridization, Fluorescence / methods*

Substances

ErbB Receptors