Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae

C Urban; K S Meyer; N Mariano; J J Rahal; R Flamm; B A Rasmussen; K Bush

doi:10.1128/AAC.38.2.392

Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae

Antimicrob Agents Chemother. 1994 Feb;38(2):392-5. doi: 10.1128/AAC.38.2.392.

Authors

C Urban¹, K S Meyer, N Mariano, J J Rahal, R Flamm, B A Rasmussen, K Bush

Affiliation

¹ Department of Medicine, New York Hospital Medical Center of Queens, Flushing 11355.

Abstract

An epidemic of nosocomial ceftazidime-resistant Klebsiella pneumoniae was correlated with production of a ceftazidime-hydrolyzing enzyme with an isoelectric point of 5.6 (BMH-1). BMH-1 was encoded on a large transferable plasmid conferring multiple antibiotic resistance. The gene that encodes BMH-1 was identical to the gene that encodes the TEM-26 extended-spectrum beta-lactamase.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Ceftazidime / pharmacology*
DNA, Bacterial / genetics
Drug Resistance, Microbial
Humans
Isoelectric Point
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / enzymology*
Molecular Sequence Data
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

DNA, Bacterial
Ceftazidime
beta-lactamase TEM-26
beta-Lactamases