Abstract
The aim of this work was to determine whether human polymorphonuclear neutrophilic interstitial collagenase (matrix metalloproteinase 8 [MMP-8]) levels are reduced during long-term doxycycline treatment in humans with reactive arthritis. Serum MMP-8 levels were reduced (mean +/- standard error of the mean, 678.9 +/- 185.6 versus 491.2 +/- 144.8 ng of MMP-8 per ml), but not statistically significantly. However, the reduction of salivary MMP-8 levels was statistically significant (3,729 +/- 1,905.3 versus 1,866 +/- 780.0 ng of MMP-8 per ml, P < 0.05). This study demonstrated that a 2-month regimen of doxycycline can reduce MMP-8 levels in serum and especially in body fluids (i.e., saliva) containing inflammatory exudates and thus may contribute to reduced tissue destruction.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Arthritis, Reactive / blood
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Arthritis, Reactive / drug therapy*
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Arthritis, Reactive / enzymology*
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Chlamydia Infections / blood
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Chlamydia Infections / drug therapy
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Chlamydia Infections / enzymology
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Chlamydia trachomatis
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Collagenases / blood
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Collagenases / metabolism*
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Doxycycline / therapeutic use*
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Drug Administration Schedule
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Female
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Humans
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Male
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Matrix Metalloproteinase 8
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Salmonella Infections / blood
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Salmonella Infections / drug therapy
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Salmonella Infections / enzymology
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Yersinia Infections / blood
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Yersinia Infections / drug therapy
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Yersinia Infections / enzymology
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Yersinia enterocolitica
Substances
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Collagenases
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Matrix Metalloproteinase 8
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Doxycycline