Abstract
(6S)-6-Fluoroshikimic acid inhibited the growth of Escherichia coli B on minimal medium (MIC, 0.25 micrograms ml-1), and it protected mice challenged intraperitoneally with the same organism (50% protective dose, 0.06 mg kg of body weight-1). We propose that inhibitors of bacterial aromatic biosynthesis have the potential for use in human medicine.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Escherichia coli / drug effects*
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Escherichia coli / growth & development*
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Escherichia coli Infections / drug therapy
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Escherichia coli Infections / prevention & control
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Male
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Mice
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Microbial Sensitivity Tests
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Shikimic Acid / analogs & derivatives*
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Shikimic Acid / antagonists & inhibitors*
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Shikimic Acid / metabolism*
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Shikimic Acid / pharmacology
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Swine
Substances
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6-fluoroshikimic acid
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Anti-Bacterial Agents
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Shikimic Acid