A case of Isaacs syndrome with high CSF protein and a large cisterna magna

Brain Dev. 1993 Mar-Apr;15(2):129-32. doi: 10.1016/0387-7604(93)90050-i.

Abstract

An 11-year-old boy exhibited continuous muscle fiber activity. He had suffered from stiffness of his hands, difficulty in relaxing his hands after gripping, and making skilled movements with his fingers. His clinical symptoms improved after treatment with carbamazepine. Electromyography (EMG) showed that he had continuous electrical discharges both at rest and during sleep. These discharges completely disappeared after the peripheral nerve was blocked with Lidocaine. An evoked electromyogram showed suppression of abnormal discharges after the F response. These electrophysiological findings indicated that the disorder originated in the spinal anterior horn cells. CT scanning showed a large cisterna magna in the posterior cranial fossa. Protein in the cerebrospinal fluid was elevated.

Publication types

  • Case Reports

MeSH terms

  • Carbamazepine / therapeutic use
  • Cerebrospinal Fluid Proteins / metabolism*
  • Child
  • Cisterna Magna / pathology*
  • Electromyography
  • Electrophysiology
  • Humans
  • Lidocaine
  • Male
  • Muscles / pathology
  • Muscular Diseases / cerebrospinal fluid*
  • Muscular Diseases / pathology*
  • Muscular Diseases / therapy
  • Nerve Block
  • Syndrome
  • Tomography, X-Ray Computed

Substances

  • Cerebrospinal Fluid Proteins
  • Carbamazepine
  • Lidocaine