CD8+ cytotoxic T cell therapy of cytomegalovirus and HIV infection

Curr Opin Immunol. 1993 Aug;5(4):484-91. doi: 10.1016/0952-7915(93)90027-p.

Abstract

The development of CD8+ cytotoxic T cell responses to viral pathogens is crucial for the prompt resolution of acute infections and for the control of viruses which persist in the host. Thus, cytomegalovirus often causes life threatening disease in immunosuppressed humans who fail to develop or maintain CD8+ cytotoxic T cells. Similarly, the loss of CD8+ cytotoxic T cell responses to HIV correlates with the development of AIDS. Recent investigations in the immunobiology of cytomegalovirus and HIV have resulted in the application of immunotherapeutic strategies designed to reconstitute or augment deficient CD8+ cytotoxic T cell responses to these human pathogens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / therapy
  • Animals
  • Cytomegalovirus Infections / immunology
  • Cytomegalovirus Infections / therapy*
  • Disease Models, Animal
  • HIV Infections / immunology
  • HIV Infections / therapy*
  • Humans
  • Immunity
  • Immunotherapy, Adoptive*
  • Mice
  • T-Lymphocytes, Cytotoxic / immunology*
  • T-Lymphocytes, Regulatory / immunology*