[Clinical and pharmacokinetic observations on fluconazole in the management of cryptococcal meningitis]

R Bertucci; A Leggieri; C Preziosi; R Milano; C Arduino; V Veglio

[Clinical and pharmacokinetic observations on fluconazole in the management of cryptococcal meningitis]

Clin Ter. 1993 Sep;143(3):209-12.

[Article in Italian]

Authors

R Bertucci¹, A Leggieri, C Preziosi, R Milano, C Arduino, V Veglio

Affiliation

¹ Divisione C Malattie Infettive, USSL TO IV, Ospedale Amedeo di Savoia, Torino.

PMID: 8222551

Abstract

The above study was intended to evaluate certain pharmacokinetic properties as well as the pharmacological activity of fluconazole in patients with cryptococcal meningitis. The results obtained show satisfactory bioavailability of the drug in the cerebrospinal fluid and marked reduction of the number of fungi found in the liquor.

Publication types

English Abstract

MeSH terms

AIDS-Related Opportunistic Infections / cerebrospinal fluid
AIDS-Related Opportunistic Infections / drug therapy
AIDS-Related Opportunistic Infections / microbiology*
Adult
Biological Availability
Fluconazole / pharmacokinetics
Fluconazole / therapeutic use*
Humans
Male
Meningitis, Cryptococcal / cerebrospinal fluid
Meningitis, Cryptococcal / drug therapy*
Meningitis, Cryptococcal / etiology

Substances

Fluconazole