[Methodology, technical prerequisites and postoperative morbidity of intraoperative radiotherapy (IORT) of soft tissue sarcomas. Heidelberg Krankengut 6/91-9/92]

Radiologe. 1993 Sep;33(9):513-9.
[Article in German]

Abstract

Since June 1991 the IORT facility has operated a dedicated linear accelerator, which was installed within the central operating theater of the Department of Surgery. As of 9/92 a total of 28 patients suffering from peripheral (n = 20) or centrally (n = 8) located soft tissue sarcomas had been were treated. Thirteen patients revealed a primary and 15 patients a recurrent tumor. Tumor resection with negative margins was performed in 20 patients, positive margins remained in 5 patients, and gross macroscopic residual disease in 3 patients. Combined intraoperative and external beam radiotherapy was applied in 22 patients, using IORT doses of 10-20 Gy and an external beam dose of 26-50 Gy. Three patients were irradiated intraoperatively twice with a time interval of 24 h. After a median follow-up of 9.9 months, 20 patients are disease free. Two patients died 4 and 5 months after the end of therapy with rapidly progressive distant metastases. An infield failure within the external beam target volume was seen in 1 patient and local failure at the field margin of the external field in 3 patients. So far, there have been no IORT infield failures. Follow-up is performed with magnetic resonance imaging. In 3 patients a second operation was necessary because of a severe wound infection, including one patient suffering from osteomyelitis of a neighboring bone. Mild sensory neuropathy occurred in 1 patient 7 months after treatment. Overall only mild and reversible postoperative and posttherapeutic complications were seen.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Combined Modality Therapy
  • Female
  • Germany / epidemiology
  • Histiocytoma, Benign Fibrous / epidemiology
  • Histiocytoma, Benign Fibrous / radiotherapy
  • Histiocytoma, Benign Fibrous / surgery
  • Humans
  • Intraoperative Period
  • Liposarcoma / epidemiology
  • Liposarcoma / radiotherapy
  • Liposarcoma / surgery
  • Male
  • Middle Aged
  • Morbidity
  • Operating Rooms
  • Particle Accelerators
  • Radiotherapy, High-Energy
  • Sarcoma / epidemiology
  • Sarcoma / radiotherapy*
  • Sarcoma / surgery*
  • Sarcoma, Synovial / epidemiology
  • Sarcoma, Synovial / radiotherapy
  • Sarcoma, Synovial / surgery