Rapidly progressive osteolysis of the femoral head is an infrequently encountered yet rapidly disabling arthritic condition. This is a case of simultaneous osteolysis of the femoral heads in an otherwise healthy woman. Her clinical and laboratory findings support the diagnosis of rapidly progressive osteoarthritis, possibly accelerated by the use of indomethacin. Conventional total hip arthroplasty has successfully restored her ability to ambulate without pain, with stable implant fixation at the 2-year follow-up evaluation.