Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella

N K Gulavita; A E Wright; P J McCarthy; S A Pomponi; M Kelly-Borges; M Chin; M A Sills

doi:10.1021/np50099a026

Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella

J Nat Prod. 1993 Sep;56(9):1613-7. doi: 10.1021/np50099a026.

Authors

N K Gulavita¹, A E Wright, P J McCarthy, S A Pomponi, M Kelly-Borges, M Chin, M A Sills

Affiliation

¹ Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, Florida 34946.

PMID: 8254355
DOI: 10.1021/np50099a026

Abstract

34-Sulfatobastadin 13 [1] was isolated from the sponge Ianthella sp. Its structure was elucidated by nmr techniques and chemical transformation to bastadin 13 [2]. Compound 1 weakly inhibited binding to the endothelin A receptor (ETA), while compound 2 inhibited growth of Bacillus subtilis.

MeSH terms

Animals
Aorta, Thoracic / drug effects
Aorta, Thoracic / metabolism
Bacillus subtilis / drug effects
Crystallography, X-Ray
Endothelin Receptor Antagonists*
In Vitro Techniques
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Conformation
Muscle, Smooth, Vascular / drug effects
Muscle, Smooth, Vascular / metabolism
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Phenyl Ethers / chemistry
Phenyl Ethers / isolation & purification*
Phenyl Ethers / pharmacology
Porifera / chemistry*
Rats
Rats, Sprague-Dawley
Swine

Substances

Endothelin Receptor Antagonists
Peptides, Cyclic
Phenyl Ethers
34-sulfabastadin 13