Human leucocyte antigen DNA typing in Singaporean Chinese patients with Graves' disease

S H Chan; Y N Lin; G B Wee; E C Ren; K F Lui; J S Cheah

Human leucocyte antigen DNA typing in Singaporean Chinese patients with Graves' disease

Ann Acad Med Singap. 1993 Jul;22(4):576-9.

Authors

S H Chan¹, Y N Lin, G B Wee, E C Ren, K F Lui, J S Cheah

Affiliation

¹ Department of Microbiology & WHO Immunology Centre, Faculty of Medicine, National University of Singapore.

PMID: 8257062

Abstract

Human Leucocyte Antigen (HLA) A, B, C, DR, DQ and DP locus alleles in 35 Chinese patients with Graves' disease and 80 controls were typed for using serological and DNA polymerase chain reaction/sequence specific oligonucleotide (PCR/SSO) methods. B46 was found to be strongly associated with male patients (p = 0.0002; RR = 8.2, 95% confidence interval 2.1-32.2). In HLA class 1 alleles, besides B46, the frequencies of A2 and Cw1 were increased and A24 and B63 decreased in patients compared to controls. In HLA class 2 alleles, the frequencies of DRB1*1602, *0301, *1405, DRB5*02, DQB1*0502 were increased and DRB1*1501, DQB1*0301 decreased in patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
China / ethnology
Cross-Cultural Comparison*
DNA / genetics*
Gene Frequency / genetics
Graves Disease / genetics*
Histocompatibility Antigens Class I / genetics*
Histocompatibility Antigens Class II / genetics*
Humans
Male
Polymerase Chain Reaction
Risk Factors
Singapore

Substances

Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
DNA