Degradation products of streptozotocin do not induce hyperglycemia in rats

Biochem Pharmacol. 1993 Dec 3;46(11):2111-3. doi: 10.1016/0006-2952(93)90657-i.

Abstract

The present study was conducted to determine whether degradation products of streptozotocin formed under various conditions induce hyperglycemia in rats. Streptozotocin is completely degraded in pH 7.4 buffer in 4 hr and even more rapidly in plasma. Streptozotocin degradation products resulting from incubation in pH 7.4 phosphate buffer or in plasma were not diabetogenic in rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Female
  • Hydrogen-Ion Concentration
  • Hyperglycemia / chemically induced*
  • Rats
  • Rats, Sprague-Dawley
  • Streptozocin / administration & dosage
  • Streptozocin / chemistry
  • Streptozocin / pharmacokinetics*
  • Time Factors

Substances

  • Blood Glucose
  • Streptozocin