Abstract
The crude extract of Calythropsis aurea (Myrtaceae) produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Cytotoxicity-guided fractionation led to the isolation of two new chalcones, calythropsin [1] and dihydrocalythropsin [2], which were responsible for the activity. Calythropsin was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Chalcone / analogs & derivatives*
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Chalcone / isolation & purification
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Chalcone / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Leukemia L1210 / drug therapy
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Mitosis / drug effects
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Plant Extracts / analysis
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Plants, Medicinal / chemistry*
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Propiophenones / isolation & purification*
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Propiophenones / pharmacology
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Tubulin / metabolism
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Western Australia
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Propiophenones
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Tubulin
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dihydrocalythropsin
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calythropsin
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Chalcone