A cytotoxic beta-carboline from the bryozoan Catenicella cribraria

J A Beutler; J H Cardellina 2nd; T Prather; R H Shoemaker; M R Boyd; K M Snader

doi:10.1021/np50100a026

A cytotoxic beta-carboline from the bryozoan Catenicella cribraria

J Nat Prod. 1993 Oct;56(10):1825-6. doi: 10.1021/np50100a026.

Authors

J A Beutler¹, J H Cardellina 2nd, T Prather, R H Shoemaker, M R Boyd, K M Snader

Affiliation

¹ Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick, Maryland 21702-1201.

PMID: 8277321
DOI: 10.1021/np50100a026

Abstract

1-Vinyl-8-hydroxy-beta-carboline was identified as the cytotoxic constituent of the bryozoans Catenicella cribraria and Cribricellina cribraria. Literature nmr data for this previously known compound, now reported from a new source, were corrected.

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Bryozoa / chemistry*
Carbolines / chemistry
Carbolines / isolation & purification
Carbolines / pharmacology*
Chromatography, Thin Layer
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Vinyl Compounds / chemistry
Vinyl Compounds / isolation & purification
Vinyl Compounds / pharmacology*

Substances

Antineoplastic Agents
Carbolines
Vinyl Compounds
1-vinyl-8-hydroxy-beta-carboline