Reversing of chlorambucil resistance by ethacrynic acid in a B-CLL patient

Br J Haematol. 1993 Oct;85(2):409-10. doi: 10.1111/j.1365-2141.1993.tb03187.x.

Abstract

We evaluated the reversing activity of ethacrynic acid in a B-CLL patient resistant to chlorambucil. The glutathione S-transferase (GST) activity, measured in peripheral blood lymphocytes, resulted extremely elevated. Ethacrynic acid, at pharmacological concentrations, partially reversed chlorambucil resistance and this result appeared related to the increased GST levels.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chlorambucil / therapeutic use*
  • Drug Resistance
  • Ethacrynic Acid / therapeutic use*
  • Glutathione Transferase / drug effects
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
  • Leukemia, Lymphocytic, Chronic, B-Cell / enzymology
  • Leukocyte Count / drug effects
  • Lymphocytes / enzymology
  • Male

Substances

  • Chlorambucil
  • Glutathione Transferase
  • Ethacrynic Acid