Abstract
Cyclosporin A was given to five patients with acute leukaemia in whom graft-versus-host disease (G.V.H.D.) had developed after bone-marrow transplantation from sibling donors. In all instances the acute erythematous skin reaction of G.V.H.D. resolved within two days, but four of the five patients died. Cyclosporin A in high doses produced anorexia, nausea, and a reversible rise in blood-urea. The four patients who died all had liver damage, but the histological changes varied. Cyclosporin A modifies the acute skin reaction of G.V.H.D. In the management of liver and gut G.V.H.D., and in prophylaxis of G.V.H.D., its role needs to be determined.
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Bone Marrow Transplantation*
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Drug Evaluation
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Female
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Fungal Proteins / therapeutic use*
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Graft vs Host Reaction / drug effects*
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Hepatic Encephalopathy / chemically induced
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Humans
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / therapeutic use*
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Injections, Intramuscular
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Leukemia, Monocytic, Acute / therapy
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Leukemia, Myeloid, Acute / therapy
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Liver Function Tests
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Male
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Peptides / administration & dosage
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Peptides, Cyclic / therapeutic use*
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Postoperative Complications / drug therapy*
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Transplantation, Isogeneic
Substances
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Fungal Proteins
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Immunosuppressive Agents
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Peptides
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Peptides, Cyclic