In the recent few years the treatment of the stages I and II of non-Hodgkin lymphomas with the simultaneous use of several drugs showed improvement of results. In the period between 1977 and 1992 three consecutive chemotherapy programs have been developed in the "Instituto da Criança-HC-FMUSP". Between 1977 and 1980 five patients belonging to stage II were treated according to the LSA 2 L-Protocol; complete remission was attained in all of them and three patients have been kept in remission so far. In 1980-1984 period a new regimen (Protocol-I-80) was instituted using the same remission induction strategy as before adding a consolidation with Cyclo and Adria combination and a continuation phase with 6-MP+MTX; five out of six patients have survived free of events till now. In the 1984-1992 period a new protocol was designed (VM-26+ARA-C) replacing Cyclo+Adria. Five patients were included and all of them are disease free survivors.