FR901459, a novel immunosuppressant isolated from Stachybotrys chartarum No. 19392. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities

J Antibiot (Tokyo). 1993 Dec;46(12):1788-98. doi: 10.7164/antibiotics.46.1788.

Abstract

FR901459, a novel immunosuppressant, has been isolated from the fermentation broth of Stachybotrys chartarum No. 19392. The molecular formula of FR901459 was determined as C62H111N11O13. FR901459 was found to be a member of the cyclosporin family. However, it is structurally distinct from any other cyclosporins discovered so far, in that Leu is present at position 5 instead of Val. FR901459 was capable of prolonging the survival time of skin allografts in rats with one third the potency of cyclosporin A.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chemical Phenomena
  • Chemistry, Physical
  • Cyclosporine / biosynthesis
  • Cyclosporine / isolation & purification
  • Cyclosporine / pharmacology
  • Female
  • Fermentation
  • Fungal Proteins / biosynthesis
  • Fungal Proteins / isolation & purification*
  • Fungal Proteins / pharmacology*
  • Immunosuppressive Agents / isolation & purification*
  • Immunosuppressive Agents / metabolism
  • Immunosuppressive Agents / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Molecular Structure
  • Stachybotrys / chemistry
  • Stachybotrys / classification*
  • Stachybotrys / metabolism*

Substances

  • Fungal Proteins
  • Immunosuppressive Agents
  • FR 901459
  • Cyclosporine