2,4-Dimethyl-6 H-pyrido[3,2-b]carbazole, an isomer of the antitumor alkaloid ellipticine via the Combes-Beyer reaction

Pharmazie. 1993 Nov;48(11):817-20.

Abstract

The synthesis of 2,4-dimethyl-6 H-pyrido[3,2-b]carbazole (2a) and of its 9-methoxy (2b) and 9-hydroxy (2c) derivatives via the Combes-Beyer reaction is described. Pyridocarbazole 2a has been obtained by two different routes. In the course of the synthesis of 2b either a partial or a total demethoxylation has been observed depending on the route employed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Ellipticines / chemical synthesis*
  • Ellipticines / pharmacology
  • Spectrophotometry, Ultraviolet

Substances

  • Antineoplastic Agents
  • Ellipticines
  • 2,4-dimethyl-6H-pyrido(3,2-b)carbazole