Significance of autoantibodies to purified proteinase 3 in systemic vasculitis

G Gaskin; A N Turner; J J Ryan; A J Rees; C D Pusey

doi:10.1007/978-1-4757-9182-2_43

Significance of autoantibodies to purified proteinase 3 in systemic vasculitis

Adv Exp Med Biol. 1993:336:287-9. doi: 10.1007/978-1-4757-9182-2_43.

Authors

G Gaskin¹, A N Turner, J J Ryan, A J Rees, C D Pusey

Affiliation

¹ Department of Medicine, Royal Postgraduate Medical School, London, UK.

PMID: 8296619
DOI: 10.1007/978-1-4757-9182-2_43

Abstract

Proteinase 3 was purified from human neutrophils and used in ELISA to examine sera from 150 patients with systemic vasculitis. It was found to be the major target of autoantibodies in Wegener's granulomatosis, and anti-proteinase 3 antibodies were also found in some patients with microscopic polyarteritis. Anti-proteinase 3 antibodies were associated with a chronic relapsing course.

MeSH terms

Antibodies, Antineutrophil Cytoplasmic
Antibody Specificity
Autoantibodies / blood*
Autoantibodies / immunology
Autoantigens / immunology
Granulomatosis with Polyangiitis / immunology
Humans
Immunoglobulin G / blood
Immunoglobulin G / immunology
Myeloblastin
Neutrophils / enzymology
Neutrophils / immunology*
Serine Endopeptidases / immunology*
Vasculitis / immunology*

Substances

Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Autoantigens
Immunoglobulin G
Serine Endopeptidases
Myeloblastin