Little evidence for anti-endothelial-cell antibodies in microscopic polyarteritis and Wegener's granulomatosis

M Varagunam; A C Nwosu; D Adu; C Garner; C M Taylor; J Michael; R A Thompson

doi:10.1007/978-1-4757-9182-2_73

Little evidence for anti-endothelial-cell antibodies in microscopic polyarteritis and Wegener's granulomatosis

Adv Exp Med Biol. 1993:336:419-22. doi: 10.1007/978-1-4757-9182-2_73.

Authors

M Varagunam¹, A C Nwosu, D Adu, C Garner, C M Taylor, J Michael, R A Thompson

Affiliation

¹ Renal Research Laboratory, Queen Elizabeth Hospital, Edgbaston, Birmingham.

PMID: 8296647
DOI: 10.1007/978-1-4757-9182-2_73

Abstract

Sera from patients with a vasculitis and controls were investigated for the presence of anti-endothelial cell antibodies(AECA), anti- neutrophil cytoplasmic antibodies(ANCA) and anti-myeloperoxidase (MPO) antibodies. Only 19% of patients with Wegener's granulomatosis and 2% of patients with microscopic polyarteritis had AECA. Our data suggests that AECA are a minor antibody system in vasculitis.

MeSH terms

Antibodies, Antineutrophil Cytoplasmic
Arteritis / immunology*
Autoantibodies / blood*
Autoantigens / immunology
Endothelium, Vascular / immunology*
Granulomatosis with Polyangiitis / immunology*
Humans
Immunoglobulin G / blood
Immunoglobulin M / blood
Peroxidase / immunology

Substances

Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Autoantigens
Immunoglobulin G
Immunoglobulin M
Peroxidase